This Molecule Could Make Your Workout More Effective for Weight Loss

Exercise is essential for weight loss, but it seems easier for some people than others. New research highlights subtle differences in a molecule involved in metabolism, potentially explaining why.

Key Molecule: PGC-1⍺

The molecule PGC-1⍺ plays a role in breaking down carbohydrates and fats. While linked to exercise and weight loss, its mechanisms weren’t fully understood. Researchers from Japan discovered that variants PGC-1αb and PGC-1αc are key to boosting exercise effectiveness for weight loss.

Research Findings

Kobe University biomedical scientist Kazuhiro Nomura and his team found that increased expression of PGC-1αb and PGC-1αc in mice led to higher energy output. Tests on mice and ten male humans involved treadmill and exercise bike workouts. Tissue samples showed changes in muscle metabolism, fat burning, and oxygen consumption.

Mice and Human Tests

Mice bred without PGC-1αb and PGC-1αc proteins became obese and had high insulin levels. In humans, exercise boosted these protein levels, improving metabolism. This suggests that producing PGC-1αb and PGC-1αc is linked to easier weight management.

Implications

Endocrinologist Ogawa Wataru from Kobe University confirms that genes in skeletal muscle influence obesity susceptibility. Although further research is needed, these findings hint at why exercise impacts weight loss differently for everyone. Managing PGC-1αb and PGC-1αc activity could lead to new weight loss treatments.

Future Possibilities

Ogawa suggests that finding a substance to increase PGC-1αb and PGC-1αc could lead to drugs enhancing energy expenditure during or even without exercise. Such drugs could potentially treat obesity without dietary restrictions.

Understanding the role of PGC-1αb and PGC-1αc in metabolism could revolutionize weight loss treatments, making exercise more effective for everyone.

References

• Kobe University
• BMJ Open Sport & Exercise Medicine